Resources

From evidence to impact

Peer-reviewed research and fresh thinking on the future of mental health.

Research Papers

9/29/2025

Safety Evaluation of a Clinical-Grade Generative AI Agent for Anxiety and Depression Symptoms

Preprint

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5/13/2025

Combining Artificial Intelligence and Human Support in Mental Health: Digital Intervention With Comparable Effectiveness to Human-Delivered Care

JMIR

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4/22/2025

Acceptability of a Conversational Agent–Led Digital Program for Anxiety: Mixed Methods Study of User Perspectives

JMIR Human Factors

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4/1/2025

Self-report measures of fear learning and extinction and their association with internet-based cognitive behavioural therapy outcome

Behaviour Research and Therapy

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10/1/2023

A deep learning quantification of patient specificity as a predictor of session attendance and treatment response to internet-enabled cognitive behavioural therapy for common mental health disorders

Journal of Affective Disorders

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10/1/2023

Trajectories of depression symptoms, anxiety symptoms and functional impairment during internet-enabled cognitive-behavioural therapy

Behaviour Research and Therapy

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8/31/2023

Economic evaluation of 27,540 patients with mood and anxiety disorders and the importance of waiting time and clinical effectiveness in mental healthcare

Nature Mental Health

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6/1/2022

44-LB: Evaluating the Effectiveness of a Novel Form of Online Cognitive Behavioural Therapy for Patients with Type 2 Diabetes and Comorbid Anxiety or Depression

Diabetes

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5/7/2021

Depression subtypes and their response to cognitive behavioral therapy: A latent transition analysis

Depression and Anxiety

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Our Thinking

10/28/2026

ieso Welcomes Joe Raiker, PhD as Director of Clinical Strategy

Meet the clinical psychologist (and Mean Girls aficionado) bringing expertise across academia, pharma, and digital health to help build what's next at ieso.

5/20/2026

Digital GI Care Has an ROI Ceiling. Mental Health Is How You Break Through It.

Digital GI platforms have closed major access gaps and proven real ROI. The unaddressed mental health burden in IBS and IBD populations is capping how much further those outcomes can go.

5/7/2026

The Mental Health AI Market is Crowded. Evidence is Still Rare.

A new Hemingway Report market map shows conversational AI in mental health is moving fast, but clinical evidence remains the clearest differentiator.

4/30/2026

What Does Clinical AI for Mental Health Look Like?

On The Healthtech Podcast, ieso's Clare Palmer, PhD, gets into what responsible digital mental health demands — and where the field is headed next.

4/23/2026

Chronic Pain Programs Are Still Treating Only Half the Patient

Most MSK and chronic pain programs are built around an incomplete model. Here's what the behavioral layer they're missing is costing them — in outcomes, engagement, and ROI.

4/16/2026

Diabetes Care Needs to Account for the Mental Load

People with diabetes are more likely to experience depression and anxiety. When mental health goes unaddressed, disease management falters. Here's what integrated support changes.

4/8/2026

Chronic Illness Has a Mental Health Problem

Clinicians and scientists have understood for decades that stress, worry, and feeling down don’t stay in your mind.

3/25/2026

Women’s Health Gets Federal Attention

Insights from the inaugural Health and Human Services National Conference on Women's Health in Washington, DC.

3/10/2026

The Hormonal Blind Spot in Women's Mental Health

A reflection for International Women's Day on hormonal transitions and women's mental health risk across puberty, peripartum, and menopause — and how we can respond better.

Conversations

ieso Conversations

Sit in on unscripted conversations with the people rewiring mental healthcare.

9/29/2026

The Menopause Transition is Mental, Too

Dr. Monica Christmas of UChicago Medicine and The Menopause Society explains the physical and mental health impacts women can experience during perimenopause and menopause

8/26/2026

What a Cleveland Clinic GI Psychologist Wishes Health Leaders Understood

The science of the gut-brain connection, the mental toll of chronic GI symptoms, and why holistic care can help GI patients live better.

6/29/2026

Designing Chronic Care That Supports the Mind and Body

A candid conversation about mental health, identity, grief, acceptance, trust, joy, and what it takes to build chronic condition care that works for the whole person.

10/28/2026

ieso Welcomes Joe Raiker, PhD as Director of Clinical Strategy

Meet the clinical psychologist (and Mean Girls aficionado) bringing expertise across academia, pharma, and digital health to help build what's next at ieso.

10/6/2026

ieso Welcomes Arielle Pulverman, PhD as Head of Clinical Product

Meet the health psychologist, founder, and product leader shaping how ieso builds clinically grounded AI for mental health.

9/9/2026

The Future of AI in Mental Health: Safety, Therapy, and Human Judgment

On the Beyond the Couch podcast, ieso's Head of Clinical Strategy, Alyssa Dietz, PhD, gets into where AI earns its place in mental health support and where human clinical judgment stays non-negotiable.

9/2/2026

Listen Longer

Two years into his role, ieso CEO Kent Tangen pauses to reflect on lessons learned about leadership, ambition, humility, and building mental health support around what clinicians and patients need.

7/22/2026

ieso Welcomes Mike Chynoweth as Head of Engineering

An engineering executive who translates strategy into execution and builds teams that deliver quality at speed, Mike Chynoweth brings over 20 years of experience across healthcare, security, and regulated SaaS to ieso as Head of Engineering.

7/8/2026

Joy Isn't a Reward for Healing

Dr. Talia Cohen and Alyssa Dietz, PhD, on chronic conditions, identity, lived experience, and the mental health piece most digital health companies are still missing.

6/17/2026

CBT? ACT? What’s the Difference?

CBT and ACT are closely related, but they work differently. ACT helps you create space between yourself and your thoughts, a skill that can be helpful if you're managing the stress, uncertainty, and emotional weight of living with a chronic condition.

6/4/2026

ieso Welcomes James Dold as Head of Sales

A healthcare leader with clinical roots, James Dold brings over 20 years of experience across behavioral health, value-based care, strategic partnerships, and care delivery to ieso as Head of Sales.

9/29/2026

The Menopause Transition is Mental, Too

Dr. Monica Christmas of UChicago Medicine and The Menopause Society explains the physical and mental health impacts women can experience during perimenopause and menopause

8/26/2026

What a Cleveland Clinic GI Psychologist Wishes Health Leaders Understood

The science of the gut-brain connection, the mental toll of chronic GI symptoms, and why holistic care can help GI patients live better.

6/29/2026

Designing Chronic Care That Supports the Mind and Body

A candid conversation about mental health, identity, grief, acceptance, trust, joy, and what it takes to build chronic condition care that works for the whole person.

9/29/2025

Safety Evaluation of a Clinical-Grade Generative AI Agent for Anxiety and Depression Symptoms

Preprint

Read paper

5/13/2025

Combining Artificial Intelligence and Human Support in Mental Health: Digital Intervention With Comparable Effectiveness to Human-Delivered Care

JMIR

Read paper

4/22/2025

Acceptability of a Conversational Agent–Led Digital Program for Anxiety: Mixed Methods Study of User Perspectives

JMIR Human Factors

Read paper

4/1/2025

Self-report measures of fear learning and extinction and their association with internet-based cognitive behavioural therapy outcome

Behaviour Research and Therapy

Read paper

10/1/2023

A deep learning quantification of patient specificity as a predictor of session attendance and treatment response to internet-enabled cognitive behavioural therapy for common mental health disorders

Journal of Affective Disorders

Read paper

10/1/2023

Trajectories of depression symptoms, anxiety symptoms and functional impairment during internet-enabled cognitive-behavioural therapy

Behaviour Research and Therapy

Read paper

8/31/2023

Economic evaluation of 27,540 patients with mood and anxiety disorders and the importance of waiting time and clinical effectiveness in mental healthcare

Nature Mental Health

Read paper

6/1/2022

44-LB: Evaluating the Effectiveness of a Novel Form of Online Cognitive Behavioural Therapy for Patients with Type 2 Diabetes and Comorbid Anxiety or Depression

Diabetes

Read paper

5/7/2021

Depression subtypes and their response to cognitive behavioral therapy: A latent transition analysis

Depression and Anxiety

Read paper

2/9/2021

Early Warning Signs of a Mental Health Tsunami: A Coordinated Response to Gather Initial Data Insights From Multiple Digital Services Providers

Frontiers in Digital Health

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7/28/2020

Using technology to understand how therapist variables are associated with clinical outcomes in IAPT

The Cognitive Behaviour Therapist

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7/3/2020

Understanding the relationship between patient language and outcomes in internet-enabled cognitive behavioural therapy: A deep learning approach to automatic coding of session transcripts

Psychotherapy Research

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6/29/2020

Refining our understanding of depressive states and state transitions in response to cognitive behavioural therapy using latent Markov modelling

Psychological Medicine (Cambridge University Press)

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8/22/2019

Quantifying the Association Between Psychotherapy Content and Clinical Outcomes Using Deep Learning

JAMA Psychiatry

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5/13/2019

TIM: A Tool for Gaining Insights into Psychotherapy

WWW '19: The World Wide Web Conference

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10/2/2018

Demographic and clinical predictors of response to internet-enabled cognitive–behavioural therapy for depression and anxiety

BJPsych Open

Read paper

8/22/2009

Therapist-delivered internet psychotherapy for depression in primary care: a randomised controlled trial

The Lancet

Read paper

Ready to take your care platform to the next level?

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From evidence to impact

Research Papers

Safety Evaluation of a Clinical-Grade Generative AI Agent for Anxiety and Depression Symptoms

Combining Artificial Intelligence and Human Support in Mental Health: Digital Intervention With Comparable Effectiveness to Human-Delivered Care

Acceptability of a Conversational Agent–Led Digital Program for Anxiety: Mixed Methods Study of User Perspectives

Self-report measures of fear learning and extinction and their association with internet-based cognitive behavioural therapy outcome

A deep learning quantification of patient specificity as a predictor of session attendance and treatment response to internet-enabled cognitive behavioural therapy for common mental health disorders

Trajectories of depression symptoms, anxiety symptoms and functional impairment during internet-enabled cognitive-behavioural therapy

Economic evaluation of 27,540 patients with mood and anxiety disorders and the importance of waiting time and clinical effectiveness in mental healthcare

44-LB: Evaluating the Effectiveness of a Novel Form of Online Cognitive Behavioural Therapy for Patients with Type 2 Diabetes and Comorbid Anxiety or Depression

Depression subtypes and their response to cognitive behavioral therapy: A latent transition analysis

Our Thinking

ieso Welcomes Joe Raiker, PhD as Director of Clinical Strategy

Digital GI Care Has an ROI Ceiling. Mental Health Is How You Break Through It.

The Mental Health AI Market is Crowded. Evidence is Still Rare.

What Does Clinical AI for Mental Health Look Like?

Chronic Pain Programs Are Still Treating Only Half the Patient

Diabetes Care Needs to Account for the Mental Load

Chronic Illness Has a Mental Health Problem

Women’s Health Gets Federal Attention

The Hormonal Blind Spot in Women's Mental Health

Conversations

The Menopause Transition is Mental, Too

What a Cleveland Clinic GI Psychologist Wishes Health Leaders Understood

Designing Chronic Care That Supports the Mind and Body

All Resources

ieso Welcomes Joe Raiker, PhD as Director of Clinical Strategy

ieso Welcomes Arielle Pulverman, PhD as Head of Clinical Product

The Future of AI in Mental Health: Safety, Therapy, and Human Judgment

Listen Longer

ieso Welcomes Mike Chynoweth as Head of Engineering

Joy Isn't a Reward for Healing

CBT? ACT? What’s the Difference?

ieso Welcomes James Dold as Head of Sales

The Menopause Transition is Mental, Too

What a Cleveland Clinic GI Psychologist Wishes Health Leaders Understood

Designing Chronic Care That Supports the Mind and Body

Safety Evaluation of a Clinical-Grade Generative AI Agent for Anxiety and Depression Symptoms

Combining Artificial Intelligence and Human Support in Mental Health: Digital Intervention With Comparable Effectiveness to Human-Delivered Care

Acceptability of a Conversational Agent–Led Digital Program for Anxiety: Mixed Methods Study of User Perspectives

Self-report measures of fear learning and extinction and their association with internet-based cognitive behavioural therapy outcome

A deep learning quantification of patient specificity as a predictor of session attendance and treatment response to internet-enabled cognitive behavioural therapy for common mental health disorders

Trajectories of depression symptoms, anxiety symptoms and functional impairment during internet-enabled cognitive-behavioural therapy

Economic evaluation of 27,540 patients with mood and anxiety disorders and the importance of waiting time and clinical effectiveness in mental healthcare

44-LB: Evaluating the Effectiveness of a Novel Form of Online Cognitive Behavioural Therapy for Patients with Type 2 Diabetes and Comorbid Anxiety or Depression

Depression subtypes and their response to cognitive behavioral therapy: A latent transition analysis

Early Warning Signs of a Mental Health Tsunami: A Coordinated Response to Gather Initial Data Insights From Multiple Digital Services Providers

Using technology to understand how therapist variables are associated with clinical outcomes in IAPT

Understanding the relationship between patient language and outcomes in internet-enabled cognitive behavioural therapy: A deep learning approach to automatic coding of session transcripts

Refining our understanding of depressive states and state transitions in response to cognitive behavioural therapy using latent Markov modelling

Quantifying the Association Between Psychotherapy Content and Clinical Outcomes Using Deep Learning

TIM: A Tool for Gaining Insights into Psychotherapy

Demographic and clinical predictors of response to internet-enabled cognitive–behavioural therapy for depression and anxiety

Therapist-delivered internet psychotherapy for depression in primary care: a randomised controlled trial

Ready to take your care platform to the next level?